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Rosie O'Donnell isn't the only one this morning whose love is on the rocks.

Sources confirm that T.R. Knight and his boyfriend of about two years, Mark Cornelsen, have called it quits.

"It's amicable," one source says of the breakup, which was first reported by In Touch. "It was just a normal breakup. It just ran its course."

When exactly things fell apart is unclear because…

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T.R. Knight hasn't really been keeping up with Grey's Anatomy.

And it has nothing to do with not being on the show anymore or even the not-so-nice ending he had with Grey's creator Shonda Rhimes.

"Right now I'm working on a house so the TV is in a box, so unfortunately I don't know a lot of what's going on right now," Knight told us yesterday at L.A.'s Mark Taper Forum theater, where he's starring in the musical Parade (opening on Sunday, Oct. 4). "I have to catch up."

He did, however, manage to catch the season premiere. What did he think? Keep reading to find out…

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Eric Dane and Rebecca Gayheart allegedly have a sex tape. And they're not the only ones in it. They're joined in all their naked glory by disgraced beauty queen and former Celebrity Rehab "patient," Kari Ann Peniche.

Should we be appalled or simply amused? I say no big whoop.

What do you think?

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Didn't I tell ya T.R. Knight wanted to make a move to New York City now that he's done with Grey's Anatomy?

Knight's rep confirms the actor will star in an upcoming Broadway revival of the Tony Award-winning Lend Me a Tenor...

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T.R. Knight is going back to his theatrical roots.

Fresh from the official confirmation that the actor will not be returning to Grey's Anatomy, it's been announced that he will star as Leo Frank in an upcoming production of the musical Parade at L.A.'s Mark Taper Forum.

The show, which won two Tonys after debuting on Broadway in 1998, tells the real-life story of Frank, a Jewish Southerner who was lynched in 1915. He was accused of raping and murdering a 13-year-old girl in Georgia. It's widely believed that Frank was wrongly convicted amid growing anti-Semitic tensions in the South.

So when can we see Knight on stage?

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ABC/Vivian Zink

T.R. Knight is saying goodbye to Grey's Anatomy.

After weeks of speculation, the actor broke his silence this morning to announce he's hanging up his doctor scrubs.

"Leaving Grey's Anatomy was not an easy decision for me to make," he said in statement released by his rep. "I am extremely grateful to have had the opportunity to play this character and will miss my fellow cast and crew very much. I continue to wish them the very best, and wholeheartedly thank all of the fans who have supported me and the show with such passion and enthusiasm."

So what does show creator Shonda Rhimes have to say about all this?

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What's next for T.R. Knight?

Now that he's hanging up his Grey's Anatomy scrubs, I'm told Mr. Knight is in a New York state of mind.

"He wants to get to New York and do theater," a source said, "but there are no done deals yet."

Back in March, it was reported that he took part in a reading for a Broadway revival of Lend Me Tenor directed by Stanley Tucci and also including Alfred Molina, Tony Shalhoub, Jan Maxwell and Marian Seldes.

As I was the first to report, Knight is saying bye-bye to Grey's Anatomy after he asked to be let go because he was unhappy with his diminished presence on the show.

Knight appeared opposite Patti LuPone in a 2001 revival of Noises Off as well as in the 2003 production of Tartuffe. He last appeared on the New York stage five years ago off-Broadway in the drama Boy.

Frazer Harrison/Getty Images, Lisa O'Conner/ZUMAPress.com

Justin Chambers doesn't want T.R. Knight to hang up his scrubs just yet.

"T.R. is an amazing actor and I want him to be there as long as I'm on there," Chambers, who plays Dr. Alex Karev on Grey's Anatomy, told us the other night at the Salvatore Ferragamo benefit for L'Aquila Earthquake victims. "He's wonderful to work with."

Besides, Knight's character, Dr. George O'Malley, has so much growing to do.

"That's one great thing about the show," Chambers said. "All the characters have so much to explore. The audience followed these young interns coming into this hospital and now they're residents, but they have more to learn as far as surgery, social skills and manners."

Former Grey's star Melissa George says she's not convinced that Knight is definitely leaving. No matter what happens, she said, "He will go on to bigger and better things."

—Reporting by Dahvi Shira

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Get more Marc on Twitter @marcmalkin

There may have been a time when Katherine Heigl wanted off of Grey's Anatomy like pronto. Hey, even show creator Shonda Rhimes was thinking a lot about killing off Izzie.

So will Heigl follow in her best bud T.R. Knight's departing footsteps?

Nah. I really don't think so.

Why? Click my videoblog above to find out.

ABC/ERIC MCCANDLESS

Dr. George O'Malley is dead.

Multiple sources tell me that T.R. Knight will not be returning to Grey's Anatomy next season.

Knight's departure shouldn't come as too much of a shock...

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ABC/Eric McCandless

Move over, Grey's Anatomy. It looks like the CW is making a play for fans of the medical drama.

And we're not talking about the behind-the-scenes battles with Katherine Heigl and T.R. Knight.

The CW is developing a reality series in the same vein as Shonda Rhimes' hit ABC primetime soap.

I just got my hands on a casting notice that apparently has been sent to dozens of hospitals throughout the U.S.

Here's what they are looking for…

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Grey’s Anatomy Shonda Rhimes won't confirm or deny whether Katherine Heigl and T.R. Knight are leaving the hit ABC series.

"I'm not saying what's going to happen on the show, but that is a rumor," Rhimes told reporters at last night’s NAACP Image Awards in Los Angeles when asked if the two real-life best friends were hanging up their scrubs and saying goodbye to Seattle Grace Hospital.

Rhimes did tell another outlet that James Pickens' so-called confirmation of Heigl and Knight's departure wasn't true, but she still stopped short of denying the question on everyone's minds: Will the two costars actually be leaving?

As for the show's chatty Cathy himself, Pickens insists his comments were twisted by a celebrity tabloid to make it sound as though he were confirming their departures.

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